Ngeminyaka yoo-1990, uPfizer wayekhokela ekuphuhliseni nasekudwelisweni kwemveliso yokuqala yehlabathi engeyo-gelatin ye-capsule yemveliso, eyona mathiriyeli ekrwada eyi-cellulose ester "hydroxypropyl methyl cellulose" evela kwizityalo.Ngenxa yokuba olu hlobo olutsha lwe-capsule aluqukethe izithako zezilwanyana, ludunyiswa lishishini njenge "capsule yezityalo".Okwangoku, nangona umthamo wokuthengisa wee-capsules zezityalo kwimarike ye-capsule yamazwe ngamazwe ayiphezulu, ukuphuhliswa kwayo kunamandla kakhulu, kunye neendawo ezibanzi zokukhula kweemarike.
　　
"Ngophuhliso lwenzululwazi yezobuchwephesha kunye nezobugcisa kunye nesayensi ehambelanayo, ukubaluleka kwabancedisi bamachiza ekuveliseni amalungiselelo amayeza kuye kwaqatshelwa ngokuthe ngcembe, kwaye imeko yekhemesti iyanda."U-Ouyang Jingfeng, umphandi odibeneyo kwi-Academy yaseTshayina yeSayensi yezoNyango yaseTshayina, ubonise ukuba abaxhamli bamachiza abagcini nje ukugqiba umgangatho weefom zedosi entsha kunye namalungiselelo amatsha amachiza ukuya kwinqanaba elikhulu, kodwa bancedisa ukulungiselela ukwenza, ukuzinza, ukunyibilikisa. , ukwandisa i-solubilize, ukwandisa ukukhululwa, ukukhululwa okuqhubekayo, ukukhululwa okulawulwayo, ukuqhelaniswa, ixesha, ukubeka indawo, ukusebenza ngokukhawuleza, okusebenzayo kunye nokusebenza ixesha elide, kwaye ngandlela-thile, ukuphuhliswa komxhasi omtsha obalaseleyo kunokukhokelela ekuphuhlisweni kweklasi enkulu. kwiifom zedosi, ukuphucula umgangatho wenani elikhulu lamachiza amatsha kunye namalungiselelo, kwaye ukubaluleka kwawo kudlula kude uphuhliso lwechiza elitsha.Kwiifom zedosi yamayeza ezifana neepilisi zekhrimu, iipilisi, iinaliti, kunye ne-capsules, ii-capsules ziye zaba ziindlela eziphambili zedosi yamalungiselelo omlomo aqinileyo ngenxa ye-bioavailability ephezulu, ukuphucula ukuzinza kwamachiza, kunye nokubeka ixesha kunye nokukhululwa kweziyobisi.

Okwangoku, eyona nto iphambili yokuveliswa kwee-capsules yi-gelatin, i-gelatin yenziwe nge-hydrolysis yamathambo ezilwanyana kunye nezikhumba, kwaye i-biological macromolecule ene-ternary spiral structure, ene-biocompatibility efanelekileyo kunye neempawu zomzimba kunye neekhemikhali.Nangona kunjalo, i-gelatin capsules nayo inemida ethile kwisicelo, kwaye ukuphuhliswa kwezinto ezintsha ze-capsule shells zemvelaphi engeyiyo yezilwanyana ziye zaba yindawo eshushu kuphando lwakutsha nje lwabaxumi bamayeza.UWu Zhenghong, unjingalwazi kwiYunivesithi yaseChina yoPhando lwezamayeza, wathi ngenxa “yesifo senkomo esiphambeneyo” kumazwe aseYurophu afana neBritane, iFransi neNetherlands ngeminyaka yoo-1990 (kuquka iJapan yaseAsia, nekwathi yafumana iinkomo eziphambeneyo ezinesifo senkomo) , abantu bamazwe aseNtshona babengayithembi kakhulu inyama yenkomo kunye neemveliso ezinxulumene neenkomo (i-gelatin nayo enye yazo).Ukongeza, amaBhuda kunye nabatya imifuno bayakwazi ukumelana ne-gelatin capsules ezenziwe ngezinto ezikrwada zezilwanyana.Ngenxa yoku, ezinye iinkampani ze-capsule zangaphandle zaqala ukufunda izixhobo ezintsha ze-capsule shells ze-non-gelatin kunye nezinye izilwanyana zezilwanyana, kwaye ukubusa kwee-capsules ze-gelatin zaqala ukugungqa.

Ukufumana izixhobo ezitsha zokulungiselela ii-capsules ezingenayo i-gelatin yindlela yophuhliso lwangoku lwabaxumi bamayeza.U-Ouyang Jingfeng ubonise ukuba izinto eziluhlaza ze-capsules zezityalo okwangoku ziyi-hydroxypropyl methylcellulose, isitashi esilungisiweyo kunye nezinye i-hydrophilic polymer glues zokutya, ezifana ne-gelatin, i-carrageenan, i-xanthan gum kunye nokunye.I-Hydroxypropyl methyl cellulose capsules zinokunyibilika okufanayo, ukuqhekeka kunye ne-bioavailability ye-gelatin capsules, ngelixa zineengenelo ezithile ezingenazo ii-gelatin capsules, kodwa ukusetyenziswa kwangoku akukabikho kakhulu, ngenxa yexabiso eliphezulu lemveliso, xa kuthelekiswa ne-gelatin. I-hydroxypropyl methyl cellulose capsule yexabiso lempahla ekrwada iphezulu, ukongeza kwisantya esicothayo sejeli, okukhokelela kumjikelo omde wemveliso.

Kwimarike yamayeza yehlabathi, iicapsules zezityalo yenye yeemveliso ezikhula ngokukhawuleza.U-Wu Zhenghong uthe xa kuthelekiswa ne-gelatin capsules, ii-capsules zezityalo zineenzuzo ezicacileyo zilandelayo: Okokuqala, akukho mpendulo edibanisayo.Iicapsules zezityalo zine-inertness enamandla kwaye akulula ukunqumla kunye namaqela e-aldehyde okanye ezinye iikhompawundi.Eyesibini ifanelekile kumachiza angenawo amanzi.Ubumanzi bee-capsules zezityalo bulawulwa ngokubanzi phakathi kwe-5% kunye ne-8%, kwaye akulula ukusabela ngokwekhemikhali kunye neziqulatho, kwaye umthamo wamanzi ophantsi uqinisekisa ukuzinza kwezinto ezithintekayo kwi-hygroscopic ezithintekayo kumswakama.Okwesithathu kukuhambelana kakuhle kunye nezixhobo eziphambili zamachiza.Iicapsules zemifuno zihambelana kakuhle ne-lactose, i-dextrin, isitashi, i-microcrystalline cellulose, i-magnesium stearate kunye nezinye izinto eziphambili ezisetyenziswa ngokuqhelekileyo kumayeza.Okwesine kukuba nendawo yokuzalisa ekhululekile.Iicapsules zezityalo zineemfuno ezikhululekileyo zendawo yokusebenza yeziqulatho ezizaliswe, nokuba ziimfuno zendawo yokusebenza okanye izinga lokupasa kumatshini, elinokunciphisa iindleko zokusetyenziswa.
　
　
"Ehlabathini, ii-capsules zezityalo zisesebuntwaneni babo, amashishini ambalwa kuphela anokuvelisa iipilisi zezityalo zonyango, kwaye kuyimfuneko ukuqinisa ngakumbi uphando kwiinkqubo zokuvelisa kunye neminye imiba, ngelixa ukwandisa iinzame zokukhuthaza imarike."U-Ouyang Jingfeng ubonise ukuba okwangoku, ukuveliswa kwee-capsules ze-gelatin e-China kuye kwafikelela kwindawo yokuqala kwihlabathi, ngelixa isabelo semarike yeemveliso ze-capsule yezityalo sisephantsi.Ukongeza, ngenxa yokuba inkqubo yokuvelisa i-capsules ayitshintshanga iminyaka engaphezu kwekhulu, kwaye ukuphuculwa okuqhubekayo kwezixhobo kuyilwe ngokwenkqubo yokuvelisa i-gelatin, indlela yokusebenzisa inkqubo kunye nezixhobo zokulungiselela i-gelatin capsules ukulungiselela isityalo. ii-capsules ziye zaba lugxininiso lophando, olubandakanya isifundo esithile sezinto zenkqubo ezifana ne-viscosity, iimpawu ze-rheological kunye ne-viscoelasticity yezinto.
　　

Nangona kungenakwenzeka ukuba ii-capsules zezityalo zithathe indawo yolawulo lwee-capsules ze-gelatin ezingenanto, ii-capsules zezityalo zineenzuzo ezicacileyo zokukhuphisana kumalungiselelo amayeza emveli aseTshayina, amalungiselelo ebhayoloji kunye nokutya okusebenzayo.UZhang Youde, injineli ephezulu kwiSikolo seSayensi yezeNzululwazi kunye nobuNjineli beBeijing Institute of Technology, ukholelwa ukuba ngokuqonda okunzulu kwabantu kwii-capsules zezityalo kunye nokuguqulwa kwengcamango yeziyobisi yoluntu, imfuno yemarike yee-capsules zezityalo iya kukhula ngokukhawuleza.