(1)Imathiriyeli ekrwada

Izinto ekrwada ye HPMC capsule umgongxo ubukhulu becala ithathwe isityalo ifayibha yendalo esulungekileyo (umthi wompayina), nto leyo enokusingqongileyo, ekhuselekileyo kwaye ethembekileyo.

I-Gelatin hollow capsule ifumaneka ikakhulu kwi-collagen kwizikhumba zezilwanyana kunye namathambo.Kwinkqubo yokukhutshwa, inani elikhulu lamacandelo ekhemikhali liyongezwa, ekulula ukwazisa iintsholongwane zesifo senkomo yenkomo kunye nesifo sonyawo kunye nomlomo, njl.,.Kwiminyaka yakutshanje, isiganeko esithi "Poison Capsule" siye sabonisa iingxaki ezininzi ze-gelatin capsules zendabuko, njenge "glue yesikhumba eluhlaza okwesibhakabhaka" evezwe ngamajelo eendaba, ebangela ukuba i-chromium kwi-capsule idlule umgangatho.

(2) Ukusebenza kunye nokuzinza kweMichiza

I-HPMC yi-cellulose derivative ene-inertness enamandla, ukusetyenziswa okubanzi, iipropathi zekhemikhali ezizinzileyo, akukho ukuphendula okuxhamlayo kunye neziyobisi ezine-aldehyde, kwaye akukho kulibaziseka kokutshatyalaliswa.

I-Lysine ihlala kwi-gelatin, Xa usebenzisa i-gelatin kwi-capsule, kuya kubakho ukulibaziseka kokuphazamiseka.Umxholo wechiza onciphisa kakhulu uya kuba ne-Maillard reaction kunye ne-gelatin (i-Browning Reaction).Ukuba iyeza eliqukethe i-aldehyde, ikhemikhali esekelwe kwi-sugar reductive, okanye i-vitamin C, ngoko ayifanelekanga ukusetyenziswa kwi-capsule ye-gelatin.

(3) Isiqulatho samanzi

Isiqulatho samanzi se-gelatin hollow capsule simalunga ne-12.5% ​​ukuya kwi-17.5%.I-capsule ye-gelatin enomxholo ophezulu wamanzi ithande ukufunxa ukufuma kweziyobisi okanye ifunnwe ngamanzi ngokuzaliswa kwayo, okwenza i-capsule ithambile okanye i-brittle, echaphazela ichiza elizaliswe ngokwalo.

Umxholo wamanzi we-HPMC i-capsule engenanto imalunga ne-3% ukuya kwi-9%, engayi kusabela kunye neziqulatho zokuzalisa, kwaye inokugcina iipropati ezintle zomzimba ezifana nokuqina xa ugcwalisa imixholo yeziyobisi kwiipropati ezahlukeneyo, Ngokukodwa ezifanelekileyo kwi-hygroscopicity kunye nokuzaliswa komswakama. amayeza abuthathaka.

(4) Intsalela egciniweyo

Inxalenye ephambili ye-gelatin hollow capsule yiprotheni, ekulula ukuzala ibhaktheriya kunye ne-microorganisms.I-preservatives kunye ne-bacteriostatic agents, inokushiywa kwi-capsule ukukhusela ukukhula kwe-microbial ngexesha lokuvelisa.Ukuba isixa singaphezulu koluhlu oluthile, umxholo we-arsenic unokugqithwa ekugqibeleni.Kwangaxeshanye, i-gelatin hollow capsules kufuneka ivalwe nge-ethylene oxide emva kokuba imveliso igqityiwe, kwaye kuya kubakho i-chlorohydrin emva kokwenziwa inzala kwe-ethylene oxide.Ngelixa iintsalela zeChlorohydrin zithintelwe ukusetyenziswa.

Iicapsules ezingenanto zeHPMC akufuneki ukuba zongeze naziphi na izithinteli kwinkqubo yemveliso, akufuneki ukuba zicolwe, zikwazi ukuhlangabezana ngokupheleleyo nemigangatho yesizwe, kwaye zinempilo yeecapsules eziluhlaza ngaphandle kwayo nayiphi na intsalela kunye nezithinteli.

(5) Ugcino

I-HPMC ii-capsules ezingenanto zineemeko zokugcina ezikhululekile, kubushushu obuphakathi kwe-10 ukuya kuma-30 ° C, kunye nokufuma okuphakathi kwe-35% kunye ne-65%, engathambi okanye iqine kwaye ibe brittle.I-capsule ye-HPMC i-hollow capsule ine-friability ye-≤ 2% kwi-humidity ye-35% kunye nokuguqulwa kwe-capsule ye-≤ 1% kwiqondo lokushisa lama-80 ° C;Ukugcina kunye nokuthutha kuyo yonke imimandla yemozulu akukho ngxaki.

Iipilisi zeGelatin zixhomekeke ekunamatheleni phantsi kweemeko zomswakama ophezulu;ukuqina okanye ukuqina phantsi kweemeko zokufuma okuphantsi, kwaye ube nokuxhomekeka okuqinileyo kwiqondo lobushushu kunye nokufuma kwendawo yokugcina

(6)Ubume bendalo

Ukutsalwa kwe-HPMC ehollow capsule imathiriyeli ekrwada kuqhutywa ngokutsalwa ngokwasemzimbeni.Itsalwa kumthi wepine kwaye ayivelisi vumba elibolileyo.Ikwanciphisa kakhulu umthamo wamanzi asetyenziswayo kwaye inciphisa ukungcoliseka kwendalo.Akukho zinto eziyingozi zongezwa ngexesha lenkqubo kwaye akukho ngcoliseko yendalo.

I-Gelatin hollow capsules zenziwe ngesikhumba sesilwanyana kunye nethambo njengemathiriyeli ekrwada, eshukunyiswa yikhemikhali kwaye ivundisiwe.Inkqubo yongeza inani elikhulu lamacandelo ekhemikhali, ivelisa iphunga elikhulu ngexesha lokuvelisa, kwaye isebenzisa ubuninzi bemithombo yamanzi.Ukuvelisa ungcoliseko olumandla;Kwakhona ukugaywa kwakhona kwenkunkuma yegelatin kuphantsi, kwaye isixa esikhulu semithombo yongcoliseko iveliswa ngexesha lokulahlwa kwenkunkuma.

(7) Ukwahlula ukudibana nomoya wangaphandle

Iipropathi zezinto ezikrwada ze-HPMC ii-capsules ezingenanto zigqiba ukuba ziyakwazi ukwahlula ngokufanelekileyo imixholo evela kwihlabathi langaphandle kwaye ziphephe iziphumo ezibi kunye nomoya, kwaye ubomi beshelufu buhlala ziinyanga ezingama-24.

I-capsule ye-gelatin inexesha elisebenzayo malunga neenyanga ezili-18, ngelixa kukho ixesha lokugcina ngaphambi kokusetyenziswa lenza i-capsule ibe nobomi obufutshane be-shelf, obuchaphazela ngqo ubomi beshelufu yeziyobisi.

(8) Ukuthintela ukukhula kwebhaktiriya

Eyona mathiriyeli ekrwada yeHPMC ehollow iicapsules yifayibha yezityalo, engagcini nje ukwandisa ibhaktheriya, kodwa ikwanqanda ukukhula kwebhaktheriya.Iimvavanyo zibonise ukuba ii-capsules ezingenanto ze-HPMC zingagcinwa kwindawo eqhelekileyo ixesha elide, kwaye inani le-microorganisms lingagcinwa phantsi koluhlu oluqhelekileyo.

Eyona mathiriyeli ekrwada ye-gelatin hollow capsule yi-collagen, kwaye i-collagen yindawo yenkcubeko yebhaktiriya, enceda iibhaktheriya ukuba ziphindaphindeke.Ukuba unyango alufanelekanga, inani lebhaktheriya liya kudlula umgangatho kwaye liya kwanda.

Isiphelo.